Anti-MRP1 antibodies, human

Anti-MRP1 antibodies, human

Clone: REA481 | Dilution: 1:10
Clone REA481 recognizes an intracellular epitope of the human multidrug resistance–associated protein 1 (MRP1) antigen, a 190 kDa multi-pass membrane protein also known as ATP-binding cassette sub-family C member 1 (ABCC1) or leukotriene C(4) transporter. MRP1 was initially identified because of its ability to confer multidrug resistance in lung cancer cells. It plays a role in protecting certain tissues from xenobiotic insults and that it mediates the ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs, and other xenobiotics from the cytoplasm. MRP1 also plays a role in the cellular efflux of the reduced and oxidized forms of glutathione and thus contributes to the many physiological and pathophysiological processes influenced by these small peptides, including oxidative stress.
Additional information: Clone REA481 displays negligible binding to Fc receptors.

Alternative Names

ABCC1, ABC29, ABCC, GS-X, MRP, MRP-1

Technical specifications

  • Antigen: MRP1
  • Clone: REA481
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ABCC1, ABC29, ABCC, GS-X, MRP, MRP-1
  • Entrez Gene ID: 4363
  • Molecular mass of antigen [kDa]: 172
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected References

    1. Cole, S. P. et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258(5088): 1650-1654
    2. Leslie, E. M. et al. (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204(3): 216-237
    3. He, S. M. et al. (2011) Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1). Curr. Med. Chem. 18(3): 439-481
Product options: 6

Product information

Size
Order no.
Price

Anti-MRP1-FITC, human

  • REA481
  • 1:10
  • For research use only
for 30
tests
(1)
130-107-519
EUR 90,00 

Anti-MRP1-FITC, human

  • REA481
  • 1:10
  • For research use only
for 100
tests
(1)
130-107-466
EUR 220,00 

Anti-MRP1-PE, human

  • REA481
  • 1:10
  • For research use only
for 30
tests
(1)
130-107-520
EUR 110,00 

Anti-MRP1-PE, human

  • REA481
  • 1:10
  • For research use only
for 100
tests
(1)
130-107-467
EUR 265,00 

Anti-MRP1-APC, human

  • REA481
  • 1:10
  • For research use only
for 30
tests
(1)
130-107-521
EUR 110,00 

Anti-MRP1-APC, human

  • REA481
  • 1:10
  • For research use only
for 100
tests
(1)
130-107-468
EUR 265,00