Anti-LRP-4 antibodies, human

Anti-LRP-4 antibodies, human

Clone: REA552 | Dilution: 1:11
Clone REA552 recognizes the human LRP-4 antigen, a β-propeller containing protein, which is a member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. LRP-4 is expressed in bone and cultured osteoblasts and binds Dkk1 and sclerostin
in vitro
. It plays a physiological role in the regulation of bone growth and turnover.
Additional information: Clone REA552 displays negligible binding to Fc receptors.

Alternative Names

Lrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816

Technical specifications

  • Antigen: LRP-4
  • Clone: REA552
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Lrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816
  • Entrez Gene ID: 4038
  • Molecular mass of antigen [kDa]: 210
  • Distribution of antigen: bone, osteoblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected References

    1. Choi, H. Y. et al. (2009)
      Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover
      in vivo
      .
      PLoS One 4(11): e7930
    2. Leupin, O. et al. (2011) Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J. Biol. Chem. 286(22): 19489-19500
    3. Holdsworth, G. et al. (2012) Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors. J. Biol. Chem. 287(32): 26464-26477
Product options: 6
130-109-183

Anti-LRP-4-PE, human

for 30
tests
(1)
EUR 115,00 
130-109-136

Anti-LRP-4-PE, human

for 100
tests
(1)
EUR 270,00 
130-109-184

Anti-LRP-4-APC, human

for 30
tests
(1)
EUR 115,00 
130-109-137

Anti-LRP-4-APC, human

for 100
tests
(1)
EUR 270,00 
130-109-999

Anti-LRP-4-Biotin, human

for 30
tests
(1)
EUR 95,00 
130-109-944

Anti-LRP-4-Biotin, human

for 100
tests
(1)
EUR 230,00