Anti-IL-1A antibodies, mouse

Anti-IL-1A antibodies, mouse

Clone: REA288 | Dilution: 1:10
Clone REA288 recognizes the precursor, secreted and membrane-associated forms of the mouse interleukin-1α (IL-1α) protein. IL-1α is a unique member in the cytokine family in the sense that the structure of its initially synthesized precursor does not contain a signal peptide fragment. After processing by the removal of N-terminal amino acids by specific proteases, the resulting peptide is called "mature" form. Both the 31kDa precursor form of IL-1α and its 18kDa mature form are biologically active. IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor type I (IL-1R1).
Additional information: Clone REA288 displays negligible binding to Fc receptors.

Alternative names

Interleukin-1 α (IL-1 α)

Technical specifications

  • Antigen: IL-1A
  • Clone: REA288
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Interleukin-1 α (IL-1 α)
  • Entrez Gene ID: 16175
  • Molecular mass of antigen [kDa]: 18
  • Distribution of antigen: macrophages, neutrophils, epithelial cells, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Lomedico, P. T. et al. (1984) Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312(5993): 458-462
    2. Ben-Sasson, S. Z. et al. (2009) IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. U.S.A. 106: 7119-7124
    3. Sims, J. E. et al. (2010) The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10(2): 89-102
Product options: 4
9 µg in 300 µL (1)
EUR 28,00 
30 µg in 1 mL (1)
EUR 82,00 
9 µg in 300 µL (1)
EUR 45,00 
30 µg in 1 mL (1)
EUR 82,00 

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