Anti-IL-10 antibodies, human

Anti-IL-10 antibodies, human

Clone: REA842 | Dilution: 1:50
Clone REA842 recognizes the interleukin 10 (IL-10). IL-10 is a cytokine predominantly secreted by CD4
+
memory and effector T cells and antigen-presenting cells, for example, monocytes/macrophages and dendritic cells. IL-10 has important suppressive functions on immune responses and is believed to be involved in the maintenance of tolerance. IL-10 blocks activation of cytokine synthesis by Tʜ1 cells, activated monocytes, and NK cells. It can stimulate immunoglobulin production by B cells.
Additional information: Clone REA842 displays negligible binding to Fc receptors.

Alternative Names

IL10, CSIF, GVHDS, TGIF, IL10A, Interleukin-10

Technical specifications

  • Antigen: IL-10
  • Clone: REA842
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IL10, CSIF, GVHDS, TGIF, IL10A, Interleukin-10
  • Entrez Gene ID: 3586
  • Molecular mass of antigen [kDa]: 19
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: T cells, monocytes, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected References

    1. Gesser, B. et al. (1997) Identification of functional domains on human interleukin 10. Proc. Natl. Acad. Sci. U.S.A. 94(26): 14620-14625
    2. Ng, T. H. et al. (2013) Regulation of adaptive immunity; the role of interleukin-10. Front Immunol 129

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