Anti-GSK3B pS9 antibodies, human, mouse, rat

Anti-GSK3B pS9 antibodies, human, mouse, rat

Clone: REA436 | Dilution: 1:11
Clone REA436 recognizes the human, mouse, and rat glycogen synthase kinase-3 β (GSK3B) phosphorylated at serine 9 (pS9). The GSK-3 family of protein-serine kinases was initially characterized as a regulator of glycogen metabolism. The protein kinase phosphorylates residues on glycogen synthase, the rate-limiting enzyme of glycogen synthesis, that are specifically dephosphorylated in response to insulin. In mammals, two genes encode closely related proteins termed GSK3A and GSK3B. The kinase is highly conserved and has roles in a number of signal transduction pathways regulating cell growth, differentiation, and development. GSK3B activity is regulated negatively by the phosphorylation of serine 9.
Additional information: Clone REA436 displays negligible binding to Fc receptors.

Alternative Names

GSK3B, GSK-3, GSK-3beta

Technical specifications

  • Antigen: GSK3B pS9
  • Clone: REA436
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: GSK3B, GSK-3, GSK-3beta
  • Entrez Gene ID: 56637, 84027
  • Molecular mass of antigen [kDa]: 47
  • Cross-reactivity: hamster
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected References

    1. Stambolic, V. et al. (1994) Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem. J. 303(Pt 3): 701-704
    2. Cai, G. et al. (2007) Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells. Int. J. Oncol. 31(3): 657-662
    3. Giovannini, C. et al. (2013) Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma. Oncotarget 4(10): 1618-1631
Product options: 4
130-106-964

Anti-GSK3B pS9-PE, human, mouse, rat

for 30
tests
(1)
EUR 115,00 
130-106-900

Anti-GSK3B pS9-PE, human, mouse, rat

for 100
tests
(1)
EUR 270,00 
130-106-965

Anti-GSK3B pS9-APC, human, mouse, rat

for 30
tests
(1)
EUR 115,00 
130-106-901

Anti-GSK3B pS9-APC, human, mouse, rat

for 100
tests
(1)
EUR 270,00