Anti-ErbB-3 (Her-3) antibodies, human

Anti-ErbB-3 (Her-3) antibodies, human

Clone: REA508 | Dilution: 1:11
Clone REA508 recognizes the human ErbB-3 antigen, a single-pass type I membrane protein, which is also known as tyrosine kinase-type cell surface receptor HER3. ErbB-3 is a receptor tyrosine kinase and a member of the epidermal growth factor receptor family (EGFR). It is unique among the ErbB family members in that it is has been shown to have weak or no tyrosine kinase activity. After dimerization with other members of the EGFR family several signal transduction cascades can be activated, including phosphoinosite 3'-kinase (PI3-K)/Akt and extracellular signal-regulated kinase (ERK1/2). ErbB-3 is widely expressed in normal tissues including cells of the gastrointestinal, reproductive, respiratory and urinary tracts, as well as the skin, endocrine, and nervous system. It is expressed at elevated levels in a range of human malignancies.
Additional information: Clone REA508 displays negligible binding to Fc receptors.

Alternative Names

ErbB3, HER3, LCCS2, MDA-BF-1, c-ErbB-3, erbB3-S

Technical specifications

  • Antigen: ErbB-3 (Her-3)
  • Clone: REA508
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ErbB3, HER3, LCCS2, MDA-BF-1, c-ErbB-3, erbB3-S
  • Entrez Gene ID: 2065
  • Molecular mass of antigen [kDa]: 146
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Kraus, M. H. et al. (1989) Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86(23): 9193-9197
    2. Citri, A. et al. (2003) The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp. Cell Res. 284(1): 54-65
    3. Ghasemi, R. et al. (2014) Dual targeting of ErbB-2/ErbB-3 results in enhanced antitumor activity in preclinical models of pancreatic cancer. Oncogenesis 3: 117
Product options: 12

Product information

Size
Order no.
Price

Anti-ErbB-3 (Her-3)-VioBright FITC, human

  • REA508
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-965
EUR 120,00 

Anti-ErbB-3 (Her-3)-VioBright FITC, human

  • REA508
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-903
EUR 290,00 

Anti-ErbB-3 (Her-3)-PE, human

  • REA508
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-961
EUR 110,00 

Anti-ErbB-3 (Her-3)-PE, human

  • REA508
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-899
EUR 265,00 

Anti-ErbB-3 (Her-3)-APC, human

  • REA508
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-962
EUR 110,00 

Anti-ErbB-3 (Her-3)-APC, human

  • REA508
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-900
EUR 265,00 

Anti-ErbB-3 (Her-3)-PE-Vio770, human

  • REA508
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-963
EUR 120,00 

Anti-ErbB-3 (Her-3)-PE-Vio770, human

  • REA508
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-901
EUR 290,00 

Anti-ErbB-3 (Her-3)-APC-Vio770, human

  • REA508
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-964
EUR 120,00 

Anti-ErbB-3 (Her-3)-APC-Vio770, human

  • REA508
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-902
EUR 290,00 

Anti-ErbB-3 (Her-3)-Biotin, human

  • REA508
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-960
EUR 90,00 

Anti-ErbB-3 (Her-3)-Biotin, human

  • REA508
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-898
EUR 220,00