Anti-DCAR1 antibodies, mouse

Anti-DCAR1 antibodies, mouse

Clone: SKa5-3D5 | Dilution: 1:10
Dendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a
DC subsets in spleen and thymus and on subsets of CD11b
myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses
in vivo
. Triggering DCAR1 via monoclonal antibody ligation on CD8
DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice.

Alternative names


Technical specifications

  • Antigen: DCAR1
  • Clone: SKa5-3D5
  • Isotype: rat IgG2b
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: CLEC4b2, APLRA1
  • Entrez Gene ID: 69810
  • Molecular mass of antigen [kDa]: 24
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
Product options: 3
30 µg in 1 mL (1)
EUR 93,00 
30 µg in 1 mL (1)
EUR 93,00 
30 µg in 1 mL (1)
EUR 57,00 

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