Anti-APCDD1 antibodies, human

Anti-APCDD1 antibodies, human

Clone: REA887 | Dilution: 1:50
Clone REA887 recognizes the human APCDD1 antigen, a single-pass type I membrane glycoprotein also known as adenomatosis polyposis coli down-regulated 1 protein or DRAPC1. APCDD1 functions as a negative regulator of the Wnt signaling pathway, is suggested to be involved in colorectal tumorigenesis, and supports the expression and activation of β-catenin. APCDD1 is highly expressed in heart, pancreas, prostate, ovary, and in the epidermal and dermal compartments of the hair follicle. It is moderately expressed in lung, liver, kidney, spleen, thymus, colon, and peripheral lymphocytes.
Additional information: Clone REA887 displays negligible binding to Fc receptors.

Alternative names

Adenomatosis polyposis coli down-regulated 1 protein, DRAPC1, FP7019

Technical specifications

  • Antigen: APCDD1
  • Clone: REA887
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Adenomatosis polyposis coli down-regulated 1 protein, DRAPC1, FP7019
  • Entrez Gene ID: 147495
  • Molecular mass of antigen [kDa]: 56
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: heart, prostate, ovary, pancreas, lung, liver, kidney, spleen, colon, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Takahashi, M. et al. (2002) Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res. 62(20): 5651-5656
    2. Shimomura, Y. et al. (2010) APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 464(7291): 1043-1047
    3. Viale-Bouroncle, S. et al. (2015) The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells. Biochem. Biophys. Res. Commun. 457(3): 314-317

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