CD4 MicroBeads, rat

CD4 MicroBeads, rat

Rat CD4 MicroBeads have been developed for positive selection or depletion of CD4
+
cells from lymphoid organs, such as spleen and lymph nodes, from peritoneal fluid or single-cell suspensions of lung, liver, kidney, nerve, and heart tissue.

Background information

CD4 is expressed on most thymocytes, T helper cells, CD4
+
regulatory T cells, as well as on a subset of dendritic cells and, at a lower level, on macrophages and monocytes.

Downstream applications

T cells isolated with CD4 MicroBeads can be used for
in vitro1
analysis, for example, of cytokine expression or antigen specificity. Functionality of the isolated cells has been shown by several adoptive transfer experiments.
2–4
Transfer of isolated CD4
+
and CD8a
+
T cells into irradiated recipients results in donor-specific acceptance to heart transplants
2
or type V collagen-induced tolerance to lung allografts
3
. Furthermore, autoimmunity and induction of tolerance after xenogeneic thymus transplantation was studied by adoptive transfer of T cells separated by MACS® Technology.
4

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.
Product options: 1

Product information

Size
Order no.
Price

CD4 MicroBeads, rat

  • For research use only
for 1×
10
9
total cells
130-090-319
EUR 683,00