CD127 MicroBead Kit, human

CD127 MicroBead Kit, human

The CD127 MicroBead Kit has been developed for the positive selection or depletion of CD127
+
cells from human PBMCs.

Background information

CD127, the α-chain of the IL-7 receptor, is a type I membrane glycoprotein. Signaling of IL-7 through the IL-7R requires both IL-7Rα and the common cytokine gamma chain (γc).
1
CD127 can be identified on immature B cells through the early pre-B stage, on thymocytes, and on most mature T cells with transient down-regulation upon activation.
2,3
On regulatory T cells CD127 is absent
4
and its expression is inversely correlated with FoxP3 expression and suppressive function.
5,6
CD127 is also used by thymic stromal derived lymphopoietin (TSLP) as part of a complex.
1
Human regulatory T cells can be isolated, for example, by using the CD4
+
CD25
+
CD127
dim/–
Regulatory T Cell Isolation Kit, human.

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.
Product options: 1

Product information

Size
Order no.
Price

CD127 MicroBead Kit, human

  • For research use only
for 1×
10
9
total cells
130-094-945
EUR 646,00 

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