Human TRAIL

Human TRAIL

TRAIL stands for TNF-related apoptosis inducing ligand. Human TRAIL is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Alternative names

Apo2L, TNFSF10

Background information

Human TNF-related apoptosis inducing ligand (TRAIL), also known as Apo2 ligand, is part of the tumor necrosis factor (TNF) superfamily. It is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. Apoptosis is induced via the activation of caspases 8 and 10, due to the binding of TRAIL to DR4 and DR5, two death-signaling receptors.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Cytolysis of mouse L929 cells in the presence of Actinomycin D
  • research grade: ≥ 5×
    10
    5
    U/mg
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Product options: 2
E. coli
10 µg
EUR 56,00 
E. coli
50 µg
EUR 195,00