Human IL-23

Human IL-23

IL-23 stands for interleukin 23. Human IL-23 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.


Human IL-23 can be used for a variety of applications, including:
  • In vitro differentiation of CD4+ T cells towards TH 17 cells and proliferation of TH 17 cells.
  • Exploration of the role of IL-23 in autoimmune diseases or inflammatory bowel diseases.
  • Investigation of IL-23–mediated molecular signaling pathways.

Background information

Interleukin 23 (IL-23) is a covalently linked heterodimeric cytokine, which is closely related to IL-12. Macrophages and dendritic cells (DCs) are the major sources of both IL-12 and IL-23, which act on receptors primarily expressed by T cells, NK cells, and NKT cells. IL-23 consists of the p40 subunit shared with IL-12 (IL-12B, IL-12 p40, IL-23 p40) and the 19 kDa protein p19 (IL-23 p19, IL-23A). Its effects are mediated by a receptor composed of IL-12 receptor subunit B1 and an IL-23 specific subunit. While IL-12 drives the development of T
1 cells, IL-23 mediates the full differentiation and maintenance of T
17 cells. IL-23 stimulates memory CD4
rather than naive T cells and promotes the production of pro-inflammatory cytokines. As a key cytokine in the survival and proliferation of T
17 cells, IL-23 has central roles in autoimmune diseases and promotes chronic inflammation. It has been shown that single chain fusion proteins of naturally heterodimeric cytokines such as IL-12 or IL-23 are bioactive
in vitro
in vivo

Quality description

cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Induction of IFN-γ secretion by human PBMCs
  • research grade: ≥ 1×
  • Selected references

    1. Damsker, J.M. et al. (2010) Tʜ1 and Tʜ17 cells: adversaries and collaborators. Ann. N. Y. Acad. Sci. 1183: 211-221
    2. Lieschke, G.J. et al. (1997)
      Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity
      in vivo.
      Nat. Biotechnol. 15: 35-40
    3. Miller, J.M. et al. (2010)
      Vesicular stomatitis virus modified with single chain IL-23 exhibits oncolytic activity against tumor cells
      in vitro
      in vivo.
      Int. J. Infereron Cytokine Mediator Res. 2010: 63-72
  • Certificates

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    to search for Certificates of Analysis (CoA) by lot number.
Product options: 3
HEK293 cells
5 µg
EUR 144,00 
HEK293 cells
25 µg
EUR 538,00 
HEK293 cells
100 µg
EUR 1.737,00 

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