Clone:
REA1021
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Klra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F

Specifications for Ly-49F Antibody, anti-mouse, REAfinity™

Overview

Clone REA1021 recognizes the mouse Ly-49F antigen (killer cell lectin-like receptor 6), a type II transmembrane natural killer (NK) cell receptor belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands and include activating and inhibitory receptor molecules. The inhibitory receptor Ly-49F is expressed on subsets of NK cells, NK-T cells, and on a subpopulation of memory T cells in C57BL/6 mice, but not AKR/J, BALB/c, C3H/HeN, DBA/1, or SJL mice. IL-21 selectively down-regulates Ly-49F on mature NK cells.
Additional information: Clone REA1021 displays negligible binding to Fc receptors.

Alternative names

Klra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F

Detailed product information

Technical specifications

CloneREA1021
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49F
Alternative names of antigenKlra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells, T cells, NKT cells
Entrez Gene ID16637
RRIDAB_2727853, AB_2727891, AB_2727854, AB_2727892, AB_2727855, AB_2727893, AB_2727856, AB_2727894, AB_2727857, AB_2727895, AB_2727858, AB_2727896, AB_2727859, AB_2727897, AB_2727860, AB_2727898, AB_2727861, AB_2727890

References for Ly-49F Antibody, anti-mouse, REAfinity™

Publications

  1. Smith, H. R. et al. (1994) Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol. 153(3): 1068-1079
  2. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77
  3. Gays, F. et al. (2005) Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J. Immunol. 175(5): 2938-2947

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Ly-49F Antibody, anti-mouse, REAfinity™

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