Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Klra4, Chok, Klra32, Klra33, Ly-49d

Specifications for Ly-49D Antibody, anti-mouse, REAfinity™


Clone REA1020 recognizes Ly-49D, a type II transmembrane NK cell receptor belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49D is a prototypic activating member of the Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. Expression of Ly-49D is strain restricted and is found on subsets of NK cells in C57BL/6, C3H/He, and SJL but not in BALB/c, DBA/2, AKR, and CBA/J mice.
Additional information: Clone REA1020 displays negligible binding to Fc receptors.

Alternative names

Klra4, Chok, Klra32, Klra33, Ly-49d

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenKlra4, Chok, Klra32, Klra33, Ly-49d
Molecular mass of antigen [kDa]31
Distribution of antigendendritic cells, macrophages, NK cells, T cells, basophils, eosinophils, neutrophils, NKT cells
Entrez Gene ID16635
RRIDAB_2727886, AB_2727849, AB_2727887, AB_2727850

Resources for Ly-49D Antibody, anti-mouse, REAfinity™


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References for Ly-49D Antibody, anti-mouse, REAfinity™


  1. Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635
  2. Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128
  3. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77

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