Clone:
14B11
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC
Alternative names:
Klra3, Klra6, Klra8, Klra9

Specifications for Ly-49C/F/I/H Antibody, anti-mouse

Overview

Clone 14B11 recognizes a common epitope of the mouse Ly-49C/F/I/H family members which are single-pass type II C-type lectin-like membrane glycoproteins, also known as Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with other Ly-49 members. The Ly-49 receptors are encoded by a family of highly polymorphic and polygenic genes within the mouse NK gene complex which includes genes that encode both inhibitory and activating Ly-49 receptors. Ly-49 receptors recognize MHC-I and MHC-I-like proteins on normal as well as altered cells. They are described as being expressed on both the developing and mature NK cells. The inhibitory Ly-49 receptors are involved in NK cell education, a process in which NK cells acquire function and tolerance toward cells that express “self-MHC-I.” On the other hand, the activating Ly-49 receptors recognize altered cells expressing activating ligands. Ly-49 receptors have been described on multiple NK cell subsets, such as uterine NK and memory NK cells, as well as NKT cells, dendritic cells, plasmacytoid dendritic cells, macrophages, neutrophils, and cells of the adaptive immune system, such as activated T cells and regulatory CD8
+
T cells.

Alternative names

Klra3, Klra6, Klra8, Klra9

Detailed product information

Technical specifications

Clone14B11
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenLy-49C/F/I/H
Alternative names of antigenKlra3, Klra6, Klra8, Klra9
Molecular mass of antigen [kDa]31(average of subunits)
Distribution of antigenNK cells, dendritic cells, macrophages, T cells, NKT cells, neutrophils
Entrez Gene ID16634, 16637, 16640, 16639
RRIDAB_2652697, AB_2652698, AB_2652699, AB_2652700, AB_2784424

References for Ly-49C/F/I/H Antibody, anti-mouse

Publications

  1. Wong, S. et al. (1991) Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. J. Immunol. 147(4): 1417-1423
  2. Tu, M. M. et al. (2014) Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 74(14): 3684-3694
  3. Rahim, M. M. et al. (2014) Ly49 receptors: innate and adaptive immune paradigms. Front Immunol 5: 145-145

Related products for
Ly-49C/F/I/H Antibody, anti-mouse

1 products available