Clone:
REAL400
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC
Alternative names:
Ly49A, Ly49D

Specifications for Ly-49A/D Antibody, anti-mouse,
REAlease
®

Overview

Clone REAL400 is an antibody fragment derived from the full Anti-Ly-49A/D antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL400 recognizes the mouse Ly-49A and Ly-49D antigens belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of natural killer (NK) and NK-T cells. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. Clone REAL400 does not react with BALB/c, DBA/2, AKR, or CBA/J Ly-D49.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

Ly49A, Ly49D

Detailed product information

Technical specifications

CloneREAL400
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49A/D
Alternative names of antigenLy49A, Ly49D
Distribution of antigenNK cells, NKT cells
RRIDAB_2751750

Related products for
Ly-49A/D Antibody, anti-mouse,
REAlease
®

3 products available

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