Clone:
REA853
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, IF, MICS, IHC
Alternative names:
Ly49A, Ly49D

Specifications for Ly-49A/D Antibody, anti-mouse, REAfinity™

Overview

Clone REA853 recognizes the mouse Ly-49A and Ly-49D antigens belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK T cells. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12.
Clone REA853 does not react with BALB/c, DBA/2, AKR, or CBA/J Ly-D49D.
Additional information: Clone REA853 displays negligible binding to Fc receptors.

Alternative names

Ly49A, Ly49D

Detailed product information

Technical specifications

CloneREA853
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49A/D
Alternative names of antigenLy49A, Ly49D
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells, NKT cells
Entrez Gene ID16627, 16635
RRIDAB_2652686, AB_2652687, AB_2652688, AB_2652689, AB_2652690, AB_2652691, AB_2652692, AB_2652693, AB_2652694, AB_2652695, AB_2652696, AB_2652685

References for Ly-49A/D Antibody, anti-mouse, REAfinity™

Publications

  1. Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635
  2. Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128
  3. Takei, F. et al. (1997) The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155: 67-77
  4. Ortaldo, J. R. et al. (1998)
    The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3
    +
    cells.
    J. Immunol. 160(3): 1158-1165
  5. Ortaldo, J. R. et al. (1999) Ly-49 receptor expression and functional analysis in multiple mouse strains. J. Leukoc. Biol. 66(3): 512-520
  6. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77
  7. Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165: 6922-6932

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