Clone:
REA1018
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Klra1, CH29-493D4.3, Klra22, Ly49v

Specifications for Ly-49A Antibody, anti-mouse, REAfinity™

Overview

Clone REA1018 recognizes th mouse Ly-49A antigen, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk, and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells.
Additional information: Clone REA1018 displays negligible binding to Fc receptors.

Alternative names

Klra1, CH29-493D4.3, Klra22, Ly49v

Detailed product information

Technical specifications

CloneREA1018
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49A
Alternative names of antigenKlra1, CH29-493D4.3, Klra22, Ly49v
Molecular mass of antigen [kDa]30
Distribution of antigenNK cells, NKT cells
Entrez Gene ID16627
RRIDAB_2727828, AB_2727838, AB_2727829, AB_2727839, AB_2727830, AB_2727840, AB_2727841, AB_2727842, AB_2727843, AB_2727844, AB_2727845, AB_2727837

References for Ly-49A Antibody, anti-mouse, REAfinity™

Publications

  1. Daws, M. R. et al. (1999) H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology 97(4): 656-664
  2. Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165: 6922-6932
  3. Zimmer, J. et al. (2001)
    H-2D ligand expression by Ly49A
    +
    natural killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function.
    J. Exp. Med. 194(10): 1531-1539

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