Clone:
REA412
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR

Specifications for LT-βR Antibody, anti-human, REAfinity™

Overview

Clone REA412 recognizes the human lymphotoxin beta receptor (LT-ßR) antigen, a 47 kDa single-pass type I membrane protein which is also known as tumor necrosis factor receptor superfamily member 3 (TNF-RIII). LT-ßR is a member of the TNF receptor family that play a role in the development and organization of lymphoid tissues. Unlike the other TNF receptors, LT-ßR does not bind a soluble ligand, but rather, a membrane form of a heterotrimeric lymphotoxin complex comprised of one LTα and two LTβ molecules. The development of lymph nodes is a process that involves the LT-ßR dependent crosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cells. Cell death induced by LT-ßR is dependent on TRAF3, whereas NFκB activation appears to be mediated by TRAF5 or TRAF2. LT-ßR is expressed on a variety of human primary and transformed cells, but is absent on T or B lymphocytes and primary monocytes or peripheral dendritic cells, although LT-ßR is detected on some myeloid leukemic lines. In the developing thymus LT-ßR is prominent along the trabeculae and into the medulla up to corticomedullary junction. In the spleen, LT-ßR is prominently expressed by cells in the red pulp and along the borders of red and white pulp which colocalizes with reticular stromal cells.
Additional information: Clone REA412 displays negligible binding to Fc receptors.

Alternative names

TNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR

Detailed product information

Technical specifications

CloneREA412
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenLT-βR
Alternative names of antigenTNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR
Molecular mass of antigen [kDa]44(refers to canonical form)
Distribution of antigenstromal cells, red pulp, spleen, white pulp
Entrez Gene ID4055
RRIDAB_2652658, AB_2652659, AB_2652660, AB_2652661, AB_2652662, AB_2652663, AB_2652664, AB_2652665, AB_2652666, AB_2652657

References for LT-βR Antibody, anti-human, REAfinity™

Publications

  1. Onder, L. et al. (2013) Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J. Exp. Med. 210(3): 465-473
  2. Crowe, P.D. et al. (1994) A lymphotoxin-beta-specific receptor. Science 264(5159): 707-710
  3. Rooney, I.A. et al. (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275(19): 14307-14315

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