Clone:
REA350
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CDF, DIA, HILDA, MLPLI, LIF, HSF III, D factor, Emfilermin

Specifications for LIF Antibody, anti-human, REAfinity™

Overview

Clone REA350 recognizes the human leukemia inhibitory factor (LIF) antigen, a secreted variably glycosylated 180 amino acid protein also known as melanoma-derived lipoprotein lipase inhibitor (MLPLI). LIF is produced by a variety of cells including activated T cells and macrophages, myeloid cells, fibroblasts, liver, heart, and melanoma cells. It affects cell growth by inhibiting differentiation. Other properties attributed to the cytokine include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Additional information: Clone REA350 displays negligible binding to Fc receptors.

Alternative names

CDF, DIA, HILDA, MLPLI, LIF, HSF III, D factor, Emfilermin

Detailed product information

Technical specifications

CloneREA350
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenLIF
Alternative names of antigenCDF, DIA, HILDA, MLPLI, LIF, HSF III, D factor, Emfilermin
Molecular mass of antigen [kDa]20
Distribution of antigenstem cells, fibroblasts, T cells, macrophages, ES and iPS cells, embryonic germ cells, heart, liver, melanoma
Entrez Gene ID3976
RRIDAB_2652644, AB_2652645, AB_2652646, AB_2652643

References for LIF Antibody, anti-human, REAfinity™

Publications

  1. Moreau, J. F. et al. (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336(6200): 690-692
  2. Martello, G. et al. (2013) Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor. EMBO J. 32(19): 2561-2574
  3. Smith, A. G. (2001) Embryo-derived stem cells: of mice and men. Annu. Rev. Cell Dev. Biol. 17: 435-462

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