Clone:
CH6-17E5.1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
TGFB1, CED, DPD1

Specifications for LAP (TGF-β1) Antibody, anti-human

Overview

Clone CH6-17E5.1 reacts with the N-terminal latency-associated peptide (LAP) of the transforming growth factor β1 (TGF-β1) dimer. TGF-β1 belongs to a family of homologous, disulfide-linked, homodimeric proteins. These highly pleiotropic cytokines inhibit proliferation of most cells, but can promote the growth of mesenchymal cells and enhance extracellular matrix formation. The pivotal function of TGF-β1 in the immune system is to mediate immunosuppression and maintain tolerance by regulating lymphocyte proliferation, differentiation, and survival. TGF-β1 is produced by many cell types, but is reported to be most abundant in mammalian platelets and bone. It is secreted predominantly as an inactive latent complex. After proteolytical processing of the TGF-β1 precursor, the resulting N-terminal latency-associated peptide (LAP) remains non-covalently associated with the TGF-β1 dimer. Mature and biologically active TGF-β1 can be released from the complex by action of proteases and/or conformational changes. LAP-TGF-β1 was recently described to be expressed on the cell surface of activated human regulatory T cells.

Alternative names

TGFB1, CED, DPD1

Detailed product information

Technical specifications

CloneCH6-17E5.1
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenLAP (TGF-β1)
Alternative names of antigenTGFB1, CED, DPD1
Molecular mass of antigen [kDa]28
Entrez Gene ID7040
RRIDAB_2857760, AB_2857747, AB_2659984, AB_2659985, AB_2659986, AB_2659987, AB_2659988

References for LAP (TGF-β1) Antibody, anti-human

Publications

  1. Tran, D.Q. et al. (2009)
    Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FoxP3
    +
    regulatory T cells allows for their purification from expansion cultures.
    Blood 113: 5125-5133
  2. Tran, D. Q. et al. (2009)
    GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3
    +
    regulatory T cells.
    Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450

Related products for
LAP (TGF-β1) Antibody, anti-human

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?