Clone:
REA895
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MC
Alternative names:
BCGF-1, BCGF1, BSF-1, BSF1

Extended validation for IL-4 Antibody, anti-human, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA895
8D4-8-
MP4-25D2++
3010.211++
3007-
7A3-3-
1A6.10+
Cells were incubated with an excess of purified unconjugated IL-4 (REA895) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for IL-4 Antibody, anti-human, REAfinity™

Overview

Clone REA895 recognizes the human interleukin-4 (IL-4), which is predominantly secreted by activated CD4
+
memory and effector Tʜ2 cells, basophils, and mast cells. It induces and supports humoral immune responses for the neutralization of extracellular pathogens. The Tʜ2 types of immune mechanisms can also be involved in immunological disorders such as IgE-mediated allergy.
Additional information: Clone REA895 displays negligible binding to Fc receptors.

Alternative names

BCGF-1, BCGF1, BSF-1, BSF1

Detailed product information

Technical specifications

CloneREA895
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate, other
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
, pig, porcine
AntigenIL-4
Alternative names of antigenBCGF-1, BCGF1, BSF-1, BSF1
Molecular mass of antigen [kDa]15
Distribution of antigenmast cells, basophils
Entrez Gene ID3565
RRIDAB_2726830, AB_2726798, AB_2726831, AB_2726799, AB_2726832, AB_2726800

References for IL-4 Antibody, anti-human, REAfinity™

Publications

  1. Yokota, T. et al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc. Natl. Acad. Sci. U.S.A. 83(16): 5894-5898
  2. Abrams, J. S. et al. (192) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127: 5-24
  3. Brown, M. A. et al. (1997) Functions of IL-4 and control of its expression. Crit. Rev. Immunol. 17(1): 1-32

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