Clone:
REA288
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Interleukin-1 α (IL-1 α)

Specifications for IL-1A Antibody, anti-mouse, REAfinity™

Overview

Clone REA288 recognizes the precursor, secreted and membrane-associated forms of the mouse interleukin-1α (IL-1α) protein. IL-1α is a unique member in the cytokine family in the sense that the structure of its initially synthesized precursor does not contain a signal peptide fragment. After processing by the removal of N-terminal amino acids by specific proteases, the resulting peptide is called "mature" form. Both the 31kDa precursor form of IL-1α and its 18kDa mature form are biologically active. IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor type I (IL-1R1).
Additional information: Clone REA288 displays negligible binding to Fc receptors.

Alternative names

Interleukin-1 α (IL-1 α)

Detailed product information

Technical specifications

CloneREA288
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-1A
Alternative names of antigenInterleukin-1 α (IL-1 α)
Molecular mass of antigen [kDa]18
Distribution of antigenmacrophages, epithelial cells, endothelial cells, neutrophils
Entrez Gene ID16175
RRIDAB_2652383, AB_2652384, AB_2652385, AB_2652382

References for IL-1A Antibody, anti-mouse, REAfinity™

Publications

  1. Lomedico, P. T. et al. (1984) Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312(5993): 458-462
  2. Ben-Sasson, S. Z. et al. (2009) IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. U.S.A. 106: 7119-7124
  3. Sims, J. E. et al. (2010) The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10(2): 89-102

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