Clone:
REA123
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, ICFC
Alternative names:
IL12A, CLMF, NFSK, P35, IL12B, IMD28, IMD29, NKSF

Specifications for IL-12 (p70) Antibody, anti-human, REAfinity™

Overview

Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages and by dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity. It induces the production of IFN-γ alone or in synergy with IL-2, acts as a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Tʜ1)-specific immune responses by promoting the differentiation of CD4
+
cells towards a Tʜ1 phenotype while inhibiting the production of Tʜ2 cells. Clone REA123 reacts with the biologically active form of human IL-12 p70 heterodimer, but not with the p40 monomer or homodimer.
Additional information: Clone REA123 displays negligible binding to Fc receptors.

Alternative names

IL12A, CLMF, NFSK, P35, IL12B, IMD28, IMD29, NKSF

Detailed product information

Technical specifications

CloneREA123
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIL-12 (p70)
Alternative names of antigenIL12A, CLMF, NFSK, P35, IL12B, IMD28, IMD29, NKSF
Molecular mass of antigen [kDa]57(sum of molecular weights of subunits)
Distribution of antigenmacrophages, monocytes, dendritic cells
Entrez Gene ID3592, 3593
RRIDAB_2652339, AB_2652340, AB_2652337, AB_2652338, AB_2652341

References for IL-12 (p70) Antibody, anti-human, REAfinity™

Publications

  1. D´Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398
  2. Gubler, U. et al. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. U.S.A. 88(10): 4143-4147
  3. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146

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