Clone:
REA638
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Gamma-interferon, IFN-gamma, IFNg

Specifications for IFN-γ Antibody, anti-mouse, REAfinity™

Overview

Clone REA638 recognizes the mouse interferon-γ (IFN-γ) antigen, a secreted protein which is produced by activated T, B, and NK cells. IFN-γ is a pleiotropic cytokine responsible for macrophage activation and differentiation. It induces transcription of several proinflammatory genes, such as inducible NO synthase, cyclooxygenase-2, and IL-1β, as well as MHC proteins. IFN-γ, in synergy with other cytokines such as TNF-α, inhibits proliferation of normal and transformed cells. Immunomodulatory effects of IFN-γ are exerted on a wide range of cell types expressing the high affinity receptors for IFN-γ.
Additional information: Clone REA638 displays negligible binding to Fc receptors.

Alternative names

Gamma-interferon, IFN-gamma, IFNg

Detailed product information

Technical specifications

CloneREA638
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIFN-γ
Alternative names of antigenGamma-interferon, IFN-gamma, IFNg
Molecular mass of antigen [kDa]16
Distribution of antigenT cells, B cells, NK cells
Entrez Gene ID15978
RRIDAB_2733591, AB_2727968, AB_2727924, AB_2819467, AB_2733590

References for IFN-γ Antibody, anti-mouse, REAfinity™

Publications

  1. Vila-del Sol, V. et al. (2008) IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages. J. Immunol. 181(7): 4461-4470
  2. Gray, P. W. et al. (1983) Cloning and expression of murine immune interferon cDNA. Proc. Natl. Acad. Sci. U.S.A. 80(19): 5842-5846
  3. Chan, E. D. et al. (2001) IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am. J. Physiol., Cell Physiol. 280(3): 441-450

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