Clone:
REA478
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
MHC class II

Specifications for I-Aq Antibody, anti-mouse, REAfinity™

Overview

Clone REA478 recognizes the mouse I-Aq MHC class II alloantigen. It also recognizes with I-As and I-Av.1. Reactivity with other haplotypes has not been reported. MHC (major histocompatibility complex) class II molecules are a family of molecules normally found on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. Because class II MHC is loaded with extracellular proteins, it is mainly concerned with presentation of extracellular pathogens.
Additional information: Clone REA478 displays negligible binding to Fc receptors.

Alternative names

MHC class II

Detailed product information

Technical specifications

CloneREA478
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
Antigen
I-A
q
Alternative names of antigenMHC class II
Molecular mass of antigen [kDa]27
Distribution of antigenB cells, dendritic cells, endothelial cells, macrophages, monocytes, epithelial cells
Entrez Gene ID14961
RRIDAB_2652210, AB_2652211, AB_2652212, AB_2652213, AB_2652214, AB_2652215, AB_2652216, AB_2652217, AB_2652218, AB_2652219, AB_2652220, AB_2652209

References for I-Aq Antibody, anti-mouse, REAfinity™

Publications

  1. Baumgart, M. et al. (1998) Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc. Natl. Acad. Sci. U.S.A. 95(12): 6936-6940
  2. Bäcklund, J. et al. (2013) C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann. Rheum. Dis. 72(7): 1225-1232
  3. Ishimaru, N. et al. (2018) CCL22-producing resident macrophages enhance T cell response in Sjögren's syndrome. Front Immunol 9: 2594
  4. Brand, D. D. et al. (2001) I-Aq and I-Ap bind and present similar antigenic peptides despite differing in their ability to mediate susceptibility to autoimmune arthritis. Autoimmunity 34(2): 133-145

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