NGF-β stands for nerve growth factor β. Human NGF-β is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human NGF-β

Overview

NGF-β stands for nerve growth factor β. Human NGF-β is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human NGF-β can be used for a variety of applications, including:
  • Neuronal proliferation and differentiation.
  • Induction of axonal growth.
  • Proliferation of stem Leydig cells.

Detailed product information

Background information

Nerve growth factor β (NGF-β) is the first identified member of the NGF family, also known as neurotrophins, which is characterized by a homodimeric cystine knot structure, and includes also brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). The precursor of NGF-β, pro-NGF-β, is biologically inactive and it is cleaved to generate the mature form. NGF-β acts as a potent neurotrophic factor via binding of two classes of receptors, which activate a complex intracellular cascade. NGF-β plays a central role in the sensory and sympathetic nervous system, supports the growth and maintenance of nerve and glial cells, and induces axonal growth. Besides its role in the nervous system, NGF-β can also induce differentiation and survival of B cells. NGF-β and its receptors have been associated with several psychiatric and neurodegenerative disorders, such as Alzheimer disease and multiple sclerosis. The protein sequences of human and mouse NGF-β share 90% identity and exhibit cross species activity.

Biological activity

  • Proliferation of TF-1 cells
  • research grade: ≥ 1×
    10
    6
    U/mg

Resources for Human NGF-β

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.