Human LIF stands for leukemia inhibitory factor. Human LIF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human LIF

Overview

Human LIF stands for leukemia inhibitory factor. Human LIF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human LIF may be used for a variety of applications, including:
  • Study of reprogramming and maintenance of human iPS cells to a naive-like stage.
  • Investigation of hematopoiesis, bone and neural development.

Detailed product information

Background information

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine, which is critically involved in embryonic development and blastocyst implantation. LIF belongs to the interleukin 6 family and functions through the gp130 activation of STAT3. It is a key factor that prevents embryonic stem cells (ESC) to differentiate, and it is used for maintenance of ES and iPS cultures, especially in mouse cultures. In human, LIF has a role in the reprogramming and mantainance of ES cells to a naive-like stage. Additionally, LIF affects hematopoiesis, neural development, bone and energy metabolism, and inflammation.

Biological activity

  • Proliferation of human TF-1 cells
  • research grade: ≥ 1×
    10
    7
    U/mg

Resources for Human LIF

Documents and Protocols

Background information

Premium-grade cytokine benefits

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Human LIF

Publications

  1. Barral, S. et al. (2013)
    Efficient neuronal
    in vitro
    and
    in vivo
    differentiation after immunomagnetic purification of mESC derived neuronal precursors.
    Stem Cell Res. 10(2): 133-46

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