IL-11 stands for interleukin 11. Human IL-11 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human IL-11

Overview

IL-11 stands for interleukin 11. Human IL-11 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-11 can be used for a variety of applications, including:
  • Megakaryocyte colony formation assay (in combination with IL-3).
  • Differentiation of erythroid progenitors (in combination with IL-3 and SCF).
  • Culture of primitive hematopoietic precursors (in combination with IL-4).
  • Osteoclast differentiation and maturation.

Detailed product information

Background information

Interleukin 11 (IL-11) is a multifunctional cytokine member of the IL-6 family. It is found in different organs and tissues and it is secreted by mesenchymal cells including fibroblasts, stromal cells, osteoclasts and epithelial cells. IL-11 receptor is an heterodimeric protein that is expressed by different hematopoietic lineages such as megakaryocyte, erythroid, and myeloid progenitors. In combination with other cytokines (IL-4, IL-3, and SCF), IL-11 regulates several hematopoiesis processes, including megakaryocyte maturation. IL-11 activates certain B and T cells and has a role in primary and secondary immune responses as modulator of auto-inflammation in favor of Th2 polarization and allergic reactions. In addition, IL-11 participates in the regulation of osteoclast differentiation and blastocyst implantation. IL-11 is under investigation for the treatment of osteoporosis, thrombocytopenia, and inflammatory conditions.

Biological activity

  • Proliferation of murine 7TD1 cells
  • research grade: ≥ 5×
    10
    5
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human IL-11

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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