IFN-α2b stands for interferon α2b. Human IFN-α2b s a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human IFN-α2b

Overview

IFN-α2b stands for interferon α2b. Human IFN-α2b s a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IFN-α2b can be used for a variety of applications, including:
  • Culture of myeloid and lymphoid cells in studies of anti-viral immune response.
  • Investigation of tumor cell growth and modulation of autoimmunity.
  • Study of intracellular signal transduction via activation of IFN type I receptor.

Detailed product information

Background information

Interferon alpha (IFN-α) cytokines belongs together with IFN-β to the type I interferon family, and is part of a cluster of proteins sharing more than 95% homology. IFN-α proteins are produced by several leukocytes, especially plasmacytoid dendritic cells, and share with all type I IFNs the same dimeric receptor (IFN-α R1/R2). IFN-α proteins induce a broad innate response to viral infections, but can also show immunomodulatory activities. IFN-α plays also a role in induction of fever and modulation of pain, by affecting the thermosensitivity of the hypothalamus and inducing prostaglandin-E2 release. An increased expression of IFN-α at tumor site favors dendritic cell activation and cytotoxic activity. IFN-α is usually produced as recombinant protein in two variants: IFN-α2a and IFN-α2b.

Biological activity

  • Viral resistance of bovine kidney MDBK cells
  • research grade: ≥ 2×
    10
    8
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human IFN-α2b

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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