Alternative names:
CT-1

Specifications for Human Cardiotrophin-1

Overview

Human cardiotrophin 1 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human Cardiotrophin-1 can be used for a variety of applications, including:
  • Induction of cardiac myocyte hypertrophy
  • Stimulation survival of cardiac and neuronal cells

Alternative names

CT-1

Detailed product information

Background information

Human Cardiotrophin-1 (CT-1) belongs to the IL-6 cytokine family, which includes besides IL-6 also IL-11, LIF, CNTF, and Oncostatin M. The pleiotropic cytokine is expressed in different tissues, such as heart, skeletal muscle, prostate, liver, lung, or kidney and affects the various cell types via its interaction with the LIF receptor/gp130 receptor heterodimer. Cardiotrophin-1 can, for example, induce hypertrophy in cardiac myocyte, promotes survival of neuronal cells as well as cardiomyocytes and has been shown to be associated with several heart diseases.

Biological activity

  • The ED50 is determined by proliferation assay using TF-1 cells.
  • research grade: ≥ 1×
    10
    6
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human Cardiotrophin-1

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.