Clone:
REA1031
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Specifications for HLA-E Antibody, anti-human, REAfinity™

Overview

Clone REA1031 recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on natural killer (NK) cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity.
Additional information: Clone REA1031 displays negligible binding to Fc receptors.

Alternative names

QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Detailed product information

Technical specifications

CloneREA1031
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-E
Alternative names of antigenQA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E
Molecular mass of antigen [kDa]38
Entrez Gene ID3133
RRIDAB_2733610, AB_2733750, AB_2733751, AB_2733326, AB_2733327, AB_2732950, AB_2732951, AB_2733490, AB_2733491, AB_2733609

References for HLA-E Antibody, anti-human, REAfinity™

Publications

  1. Lu, L. et al. (2008)
    Generation and regulation of CD8
    +
    regulatory T cells.
    Cell. Mol. Immunol. 5(6): 401-406
  2. Jiang, H. et al. (2010)
    HLA-E-restricted regulatory CD8
    +
    T cells are involved in development and control of human autoimmune type 1 diabetes.
    J. Clin. Invest. 120(10): 3641-3650
  3. Pietra, G. et al. (2010)
    The emerging role of HLA-E-restricted CD8
    +
    T lymphocytes in the adaptive immune response to pathogens and tumors.
    J. Biomed. Biotechnol. : 907092

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