Clone:
REA143
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
HLA-B, AS, SPDA1

Specifications for HLA Class I Bw6 Antibody, anti-human, REAfinity™

Overview

Clone REA143 recognizes HLA Bw6, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Downregulation of HLA class I Bw6 allele has been reported in leukemic patients where it is suggested that via this downregulation, leukemic cells may circumvent attack by CTLs.
Additional information: Clone REA143 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Detailed product information

Technical specifications

CloneREA143
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA Class I Bw6
Alternative names of antigenHLA-B, AS, SPDA1
Molecular mass of antigen [kDa]32
Entrez Gene ID3106
RRIDAB_2819460, AB_2819663, AB_2652023, AB_2652024, AB_2652025, AB_2652026, AB_2652027, AB_2652028, AB_2652029, AB_2652030, AB_2652031, AB_2652032, AB_2652033, AB_2652034, AB_2652035, AB_2652036, AB_2652037, AB_2652038, AB_2819475

References for HLA Class I Bw6 Antibody, anti-human, REAfinity™

Publications

  1. Demanet, C. et al. (2004) Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack? Blood 103: 3122-3130
  2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
  3. Jung, CJ. et al. (2015) Comparative analysis of piggyBac, CRISPR/Cas9 and TALEN mediated BAC transgenesis in the zygote for the generation of humanized SIRPA rats. PLoS Pathog. 11: 31455

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