Clone:
REA274
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HLA-B, AS, SPDA1

Specifications for HLA Class I Bw4 Antibody, anti-human, REAfinity™

Overview

Clone REA274 recognizes HLA Bw4, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Analysis of HIV-infected patients found the combination of the NK cell receptor KIR3DS1/L1 and a presumptive HLA Bw4 ligand to be correlated with slower progression to AIDS.
Additional information: Clone REA274 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Detailed product information

Technical specifications

CloneREA274
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA Class I Bw4
Alternative names of antigenHLA-B, AS, SPDA1
Molecular mass of antigen [kDa]38
Distribution of antigenT cells
Entrez Gene ID3106
RRIDAB_2652009, AB_2652010, AB_2652011, AB_2652012, AB_2652013, AB_2652014, AB_2652015, AB_2652016, AB_2652017, AB_2652018

References for HLA Class I Bw4 Antibody, anti-human, REAfinity™

Publications

  1. Carr, W. H. et al. (2005) KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand. J. Immunol. 175(8): 5222-5229
  2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
  3. Martin, M. P. et al. (2007) Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat. Genet. 39(6): 733-740
  4. Garrido, C. et al. (2016) HIV latency-reversing agents have diverse effects on natural killer cell function. Front Immunol 7: 356

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