Clone:
REA127
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HLA-A

Specifications for HLA-A9 Antibody, anti-human, REAfinity™

Overview

Clone REA127 recognizes HLA A9, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA127 displays negligible binding to Fc receptors.

Alternative names

HLA-A

Detailed product information

Technical specifications

CloneREA127
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-A9
Alternative names of antigenHLA-A
Molecular mass of antigen [kDa]38
Distribution of antigengranulocytes, epithelial cells, B cells, dendritic cells, macrophages, NK cells, T cells
Entrez Gene ID3105
RRIDAB_2652069, AB_2652070, AB_2652071, AB_2652072, AB_2652073, AB_2652074, AB_2652075, AB_2652076, AB_2652077, AB_2652078

References for HLA-A9 Antibody, anti-human, REAfinity™

Publications

  1. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169

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