Clone:
REA142
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HLA-A

Specifications for HLA-A2, A28 Antibody, anti-human, REAfinity™

Overview

Clone REA142 recognizes HLA A2 and HLA A28, class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA142 displays negligible binding to Fc receptors.

Alternative names

HLA-A

Detailed product information

Technical specifications

CloneREA142
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-A2, A28
Alternative names of antigenHLA-A
Molecular mass of antigen [kDa]38
Distribution of antigenB cells, dendritic cells, granulocytes, epithelial cells, lymphocytes, leukocytes
Entrez Gene ID3105
RRIDAB_2652039, AB_2652040, AB_2652041, AB_2652042, AB_2652043, AB_2652044, AB_2652045, AB_2652046, AB_2652047, AB_2652048, AB_2652049, AB_2652050, AB_2652051, AB_2652052, AB_2652053, AB_2652054, AB_2652055, AB_2652056

References for HLA-A2, A28 Antibody, anti-human, REAfinity™

Publications

  1. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169

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