Clone:
REA436
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
GSK3B, GSK-3, GSK-3beta

Specifications for GSK3B pS9 Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA436 recognizes the human, mouse, and rat glycogen synthase kinase-3 β (GSK3B) phosphorylated at serine 9 (pS9). The GSK-3 family of protein-serine kinases was initially characterized as a regulator of glycogen metabolism. The protein kinase phosphorylates residues on glycogen synthase, the rate-limiting enzyme of glycogen synthesis, that are specifically dephosphorylated in response to insulin. In mammals, two genes encode closely related proteins termed GSK3A and GSK3B. The kinase is highly conserved and has roles in a number of signal transduction pathways regulating cell growth, differentiation, and development. GSK3B activity is regulated negatively by the phosphorylation of serine 9.
Additional information: Clone REA436 displays negligible binding to Fc receptors.

Alternative names

GSK3B, GSK-3, GSK-3beta

Detailed product information

Technical specifications

CloneREA436
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivityhamster
AntigenGSK3B pS9
Alternative names of antigenGSK3B, GSK-3, GSK-3beta
Molecular mass of antigen [kDa]47
Entrez Gene ID56637, 84027
RRIDAB_2651903, AB_2651904, AB_2651905, AB_2651902

References for GSK3B pS9 Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Stambolic, V. et al. (1994) Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem. J. 303(Pt 3): 701-704
  2. Cai, G. et al. (2007) Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells. Int. J. Oncol. 31(3): 657-662
  3. Giovannini, C. et al. (2013) Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma. Oncotarget. 4(10): 1618-1631

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