Clone:
ACSA-1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
SLC1A3, EA6, EAAT1, GLAST1

Specifications for GLAST (ACSA-1) Antibody, anti-human/mouse/rat

Overview

The antibody ACSA-1 (astrocyte cell surface antigen-1) is specific for an extracellular epitope of the astrocyte specific transmembrane glycoprotein GLAST in the central nervous system (CNS). Besides GLT-1, GLAST is the most abundant glutamate transporter and is predominantly expressed by astrocytes in the developing and neonatal mammalian CNS. Also radial glia, which belong to the astrocyte lineage and play important roles in development, are known to express GLAST. Postnatally, radial glia only persist in a few regions, such as Bermann glia in the cerebellum, Müller glia in the retina, and radial glia in the dentate gyrus of the adult hippocampus.

Alternative names

SLC1A3, EA6, EAAT1, GLAST1

Detailed product information

Technical specifications

CloneACSA-1
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, mouse, rat
AntigenGLAST (ACSA-1)
Alternative names of antigenSLC1A3, EA6, EAAT1, GLAST1
RRIDAB_2733723, AB_2733472, AB_2733473, AB_2811532, AB_10829302, AB_2733722

Resources for GLAST (ACSA-1) Antibody, anti-human/mouse/rat

References for GLAST (ACSA-1) Antibody, anti-human/mouse/rat

Publications

  1. Storck, T. et al. (1992)
    Structure, expression, and functional analysis of a Na
    +
    -dependent glutamate/aspartate transporter from rat brain.
    Proc. Natl. Acad. Sci. U.S.A. 8(22): 10955-10959
  2. Kriegstein, A. R. and Götz, M. (2003) Radial glia diversity: a matter of cell fate. Glia 43: 37-43
  3. Wahle, S. and Stoffel, W. (1996) Membrane topology of the high-affinity L-glutamate transporter (GLAST- 1) of the central nervous system. J. Cell Biol. 135(6): 1867-1877
  4. Morris, L. G. et al. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat. Genet. 45(3): 253-261
  5. Jackson, W. S. et al. (2014) Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain. PLoS One 9(4): e95958
  6. Kimelberg, H.K. (2004) The problem of astrocyte identity. Neurochem. Int. 45(2-3): 191-202
  7. Mich, J. K. et al. (2014) Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife 3: e02669

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