Clone:
REA841
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
hGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18

Specifications for GITRL Antibody, anti-human, REAfinity™

Overview

Clone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses.
Additional information: Clone REA841 displays negligible binding to Fc receptors.

Alternative names

hGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18

Detailed product information

Technical specifications

CloneREA841
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenGITRL
Alternative names of antigenhGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18
Molecular mass of antigen [kDa]23
Distribution of antigenendothelial cells, kidney, ovary, testicle
Entrez Gene ID8995
RRIDAB_2651836, AB_2651837, AB_2651838, AB_2651839, AB_2651840, AB_2651841, AB_2651842, AB_2651843, AB_2651844, AB_2651845, AB_2651846, AB_2651847, AB_2651848, AB_2651835

References for GITRL Antibody, anti-human, REAfinity™

Publications

  1. Kwon, B. et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J. Biol. Chem. 274(10): 6056-6061
  2. Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218
  3. Shevach, E. M. et al. (2006) The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat. Rev. Immunol. 6(8): 613-618
  4. Tuyaerts, S. et al. (2007)
    Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4
    +
    CD25
    +
    regulatory T cells.
    J. Leukoc. Biol. 82(1): 93-105

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