Clone:
REAL735
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Glial fibrillary acidic protein

Specifications for GFAP Antibody, anti-human, REAdye_lease™

Overview

Clone REAL735 is an antibody fragment derived from the full GFAP antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL735 recognizes the human Glial fibrillary acidic protein (GFAP), the main intermediate filament protein in mature astrocytes and an important component of the cytoskeleton in astrocytes during development. GFAP is expressed exclusively in astrocytes in the central nervous system. It has been shown to be involved in astrocyte functions, which are important during regeneration, synaptic plasticity and reactive gliosis. Moreover, different subpopulations of astrocytes have been identified, which are likely to have distinctive tasks in brain physiology and pathology, and which are not only classified by their spatial and temporal appearance, but also by their specific expression of intermediate filaments, including distinct GFAP isoforms.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Glial fibrillary acidic protein

Detailed product information

Technical specifications

CloneREAL735
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenGFAP
Alternative names of antigenGlial fibrillary acidic protein
Distribution of antigenastrocytes
RRIDAB_2857785

References for GFAP Antibody, anti-human, REAdye_lease™

Publications

  1. Reeves, S. A. et al. (1989) Molecular cloning and primary structure of human glial fibrillary acidic protein. Proc. Natl. Acad. Sci. U.S.A. 86(13): 5178-5182
  2. Baba H. et al. (1997) GFAP gene expression during development of astrocyte. Dev. Neurosci. 19(1): 49-57
  3. Middeldorp, J. et al. (2011) GFAP in health and disease. Prog. Neurobiol. 93(3): 421-443