Clone:
REA435
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IHC, IF
Alternative names:
Lgals9, HUAT, LGALS9A, Gal-9, Ecalectin, HOM-HD-21

Specifications for Galectin-9 Antibody, anti-human, REAfinity™

Overview

Clone REA435 recognizes the human galectin-9 antigen, a member of the galectin family of carbohydrate-binding proteins, which is also known as ecalectin or tumor antigen HOM-HD-21. The galectin family is characterized by the presence of two or more conserved carbohydrate-recognition domains that bind galactose. Galectin-9 is widely distributed throughout various tissues and circulates at very high levels in the serum. It interacts with various ligands, the best characterized of which is the T cell immunoglobulin mucin 3 (Tim-3) cell surface molecule, widely expressed on innate and adaptive immune cells. Originally described as an eosinophil chemoattractant, Galectin-9 is now known to be an important pleiotropic immune modulator affecting numerous immune cell types. Galectin-9 is thought to be involved in the activation of innate immune responses and the downregulation of Tʜ17 and Tʜ1 responses. It can promote inflammation through triggering proinflammatory cytokine production from monocytes and inducing maturation of macrophages and monocyte-derived dendritic cells. Conversely, Galectin-9 has a major anti-inflammatory role in the induction of apoptosis in activated T cell subsets, as well as in promoting the differentiation of regulatory T cells expressing FoxP3. Galectin-9 is also involved in the apoptosis of tumor cells.
Additional information: Clone REA435 displays negligible binding to Fc receptors.

Alternative names

Lgals9, HUAT, LGALS9A, Gal-9, Ecalectin, HOM-HD-21

Detailed product information

Technical specifications

CloneREA435
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenGalectin-9
Alternative names of antigenLgals9, HUAT, LGALS9A, Gal-9, Ecalectin, HOM-HD-21
Molecular mass of antigen [kDa]40
Entrez Gene ID3965
RRIDAB_2857692, AB_2857680

References for Galectin-9 Antibody, anti-human, REAfinity™

Publications

  1. Matsumoto, R. et al. (1998) Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. J. Biol. Chem. 273(27): 16976-16984
  2. Leitner, J. et al. (2013) TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 9(3): e1003253
  3. Golden-Mason, L. et al. (2013) Galectin-9 functionally impairs natural killer cells in humans and mice. J. Virol. 87(9): 4835-4845

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