GadoSpin M is a gadolinium-based contrast agent of low molecular weight specifically formulated for pre-clinical magnetic resonance imaging (MRI).
GadoSpin M increases the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).
Upon intravenous injection, GadoSpin M is rapidly distributed in the extracellular space. No significant plasma protein–binding can be observed and the stable complex is excreted unchanged via glomerular filtration (kidneys) within hours.
Gd-DTPA does not penetrate the intact blood brain barrier and is, in fact, used in clinical

Data and images for GadoSpin M

Figures

Figure 1

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Structural formula of Gd-DTPA.

Figure 1

Structural formula of Gd-DTPA.

Specifications for GadoSpin M

Overview

GadoSpin M is a gadolinium-based contrast agent of low molecular weight specifically formulated for pre-clinical magnetic resonance imaging (MRI).
GadoSpin M increases the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).
Upon intravenous injection, GadoSpin M is rapidly distributed in the extracellular space. No significant plasma protein–binding can be observed and the stable complex is excreted unchanged via glomerular filtration (kidneys) within hours.
Gd-DTPA does not penetrate the intact blood brain barrier and is, in fact, used in clinical practice for imaging of brain tumors.

References for GadoSpin M

Publications

  1. Kiessling, F. et al. (2003) Dynamic T1-weighted monitoring of vascularization in human carcinoma heterotransplants by magnetic resonance imaging. Int. J. Cancer 104: 113-120
  2. Furman-Haran, E. et al. (1996) Angiogenic response of MCF7 human breast cancer to hormonal treatment: assessment by dynamic GdDTPA-enhanced MRI at high spatial resolution. J. Magn. Reson. Imaging 6: 195-202
  3. Bjornaes, I. et al. (2000) Measurement of the extracellular volume of human melanoma xenografts by contrast enhanced magnetic resonance imaging. Magn. Reson. Imaging 18: 41-48

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