Clone:
REA1253
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IHC, IF

Specifications for FoxP3 Antibody, anti-human, REAfinity™

Overview

Clone REA1253 recognizes the FoxP3 antigen, the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression.
Additional information: Clone REA1253 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA1253
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenFoxP3
Molecular mass of antigen [kDa]47
Distribution of antigenT cells, regulatory T cells
Entrez Gene ID50943

References for FoxP3 Antibody, anti-human, REAfinity™

Publications

  1. Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164
  2. Hori, S. et al. (2003) Control of regulatory T cell development by the transcription factor FoxP3. Science 299: 1057-1061
  3. Walker, M. R. et al. (2003)
    Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4
    +
    CD25
    -
    T cells.
    J. Clin. Invest. 112: 1437-1443
  4. Jaeckel, E. et al. (2005) Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54: 306-310
  5. Gavin, M. A. et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. U.S.A. 103: 6659-6664
  6. Ziegler, S. F. (2006) FoxP3: of mice and men. Annu. Rev. Immunol. 24: 209-226

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