Clone:
REA1079
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FCER1A, FcERI, Fce1a, Fcr-5

Specifications for FcεRIα Antibody, anti-mouse, REAfinity™

Overview

Clone REA1079 recognizes the alpha subunit of the murine high-affinity Fc receptor for IgE. The receptor is composed of one alpha, one beta, and two disulfid-linked gamma subunits, of which the alpha subunit binds IgE1. FcεRIα is expressed on mast and basophilic cells and is up-regulated in the presence of IgE. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.
Additional information: Clone REA1079 displays negligible binding to Fc receptors.

Alternative names

FCER1A, FcERI, Fce1a, Fcr-5

Detailed product information

Technical specifications

CloneREA1079
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenFcεRIα
Alternative names of antigenFCER1A, FcERI, Fce1a, Fcr-5
Molecular mass of antigen [kDa]26
Distribution of antigenmast cells, basophils
Entrez Gene ID14125
RRIDAB_2801720, AB_2801716, AB_2801721, AB_2801717, AB_2801722, AB_2801723, AB_2801718, AB_2801724, AB_2801725, AB_2801719

References for FcεRIα Antibody, anti-mouse, REAfinity™

Publications

  1. Metzger, H. et al. (1989) The receptor with high affinity for IgE. Ciba Found. Symp. 147: 93-113
  2. Yamaguchi, M. et al. (2001) Regulation of mouse mast cell surface Fc epsilon RI expression by dexamethasone. Int. Immunol. 13: 843-851
  3. Kojima, T. et al. (2007)
    Mast cells and basophils are selectively activated
    in vitro
    and
    in vivo
    through CD200R3 in an IgE-independent manner.
    J. Immunol. 179: 7093-7100

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