Clone:
REAL887
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Estrogen Receptor α, ESR, NR3A1, Estrogen receptor, ER, ER-alpha, Estradiol receptor

Specifications for ESR1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL887 is an antibody fragment derived from the full ESR1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL887 recognizes the human nuclear receptor ESR1, also known as Estrogen Receptor α or NR3A1, which is widely expressed in several tissues, including liver, lung, kidney, spleen, uterus, ovary, mammary gland, male reproductive organs, bone, heart, hypothalamus, and adipose tissue. ESR1 is a transcription factor composed of several domains, which are essential for hormone and DNA binding, and activation of transcription. Estrogen receptors play a role in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Estrogen Receptor α, ESR, NR3A1, Estrogen receptor, ER, ER-alpha, Estradiol receptor

Detailed product information

Technical specifications

CloneREAL887
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenESR1
Alternative names of antigenEstrogen Receptor α, ESR, NR3A1, Estrogen receptor, ER, ER-alpha, Estradiol receptor
Distribution of antigenovary, bone, heart, liver, lung, kidney, spleen, adipose tissue

References for ESR1 Antibody, anti-human, REAdye_lease™

Publications

  1. Bondesson, M. et al. (2015) Estrogen receptor signaling during vertebrate development. Biochim. Biophys. Acta 1849(2): 142-151
  2. Dahlman-Wright, K. et al. (2006) International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol. Rev. 58(4): 773-781
  3. Paterni, I. et al. (2014) Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. Steroids 90: 13-29