Clone:
REA508
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ErbB3, HER3, LCCS2, MDA-BF-1, c-ErbB-3, erbB3-S

Specifications for ErbB-3 (Her-3) Antibody, anti-human, REAfinity™

Overview

Clone REA508 recognizes the human ErbB-3 antigen, a single-pass type I membrane protein, which is also known as tyrosine kinase-type cell surface receptor HER3. ErbB-3 is a receptor tyrosine kinase and a member of the epidermal growth factor receptor family (EGFR). It is unique among the ErbB family members in that it is has been shown to have weak or no tyrosine kinase activity. After dimerization with other members of the EGFR family several signal transduction cascades can be activated, including phosphoinosite 3'-kinase (PI3-K)/Akt and extracellular signal-regulated kinase (ERK1/2). ErbB-3 is widely expressed in normal tissues including cells of the gastrointestinal, reproductive, respiratory and urinary tracts, as well as the skin, endocrine, and nervous system. It is expressed at elevated levels in a range of human malignancies.
Additional information: Clone REA508 displays negligible binding to Fc receptors.

Alternative names

ErbB3, HER3, LCCS2, MDA-BF-1, c-ErbB-3, erbB3-S

Detailed product information

Technical specifications

CloneREA508
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenErbB-3 (Her-3)
Alternative names of antigenErbB3, HER3, LCCS2, MDA-BF-1, c-ErbB-3, erbB3-S
Molecular mass of antigen [kDa]146
Distribution of antigenother
Entrez Gene ID2065
RRIDAB_2651653, AB_2651654, AB_2651655, AB_2651656, AB_2651657, AB_2651658, AB_2651659, AB_2651660, AB_2651661, AB_2651662, AB_2651663, AB_2651652

References for ErbB-3 (Her-3) Antibody, anti-human, REAfinity™

Publications

  1. Kraus, M. H. et al. (1989) Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86(23): 9193-9197
  2. Citri, A. et al. (2003) The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp. Cell Res. 284(1): 54-65
  3. Ghasemi, R. et al. (2014) Dual targeting of ErbB-2/ErbB-3 results in enhanced antitumor activity in preclinical models of pancreatic cancer. Oncogenesis 3: 117

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