Clone:
REA579
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Eck, Myk2, Sek2

Specifications for EphA2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA579 recognizes the mouse EphA2 antigen, which is a member of the receptor tyrosine kinases that are activated in response to binding ephrin. The ephrin receptor (Eph) family of receptor tyrosine kinases is the largest family of receptor tyrosine kinases.
Ephs are divided into two subclasses, EphAs and EphBs, based on sequence similarity and on their binding affinity to ephrin-A ligands or the transmembrane-bound ephrin-B ligands.
Eph receptors and ephrins regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels and may be involved in cell-cell interactions guiding early hindbrain development. It is up-regulated on many aggressive carcinoma cells including aggressive ovarian, cervical and breast carcinomas, and lung cancer.
Additional information: Clone REA579 displays negligible binding to Fc receptors.

Alternative names

Eck, Myk2, Sek2

Detailed product information

Technical specifications

CloneREA579
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenEphA2
Alternative names of antigenEck, Myk2, Sek2
Molecular mass of antigen [kDa]106
Distribution of antigenendothelial cells
Entrez Gene ID13836
RRIDAB_2651637, AB_2651638, AB_2651639, AB_2651640, AB_2651641, AB_2651636

References for EphA2 Antibody, anti-mouse, REAfinity™

Publications

  1. No authors listed (1997) Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell 90(3): 403-404
  2. Gilardi-Hebenstreit, P. et al. (1992) An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene 7(12): 2499-2506
  3. Ruiz, J.C. and Robertson, E.J. (1994) The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech. Dev. 46(2): 87-100

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