Clone:
REA869
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Egr-2, Krox-20, Krox20, Zfp-25

Specifications for EGR-2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA869 recognizes the mouse transcription factor EGR-2, also known as early growth response protein 2 or Krox20. EGR-2 consists of three tandem C2H2-type zinc fingers and its expression is induced by EGFR, which is important for osteoprogenitor maintenance and new bone formation. EGR-2 is found primarily in adult thymus, in the embryonic nervous system, and in mammary tumors and plays a critical role in the development of T cells and NKT cells.
Additional information: Clone REA869 displays negligible binding to Fc receptors.

Alternative names

Egr-2, Krox-20, Krox20, Zfp-25

Detailed product information

Technical specifications

CloneREA869
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenEGR-2
Alternative names of antigenEgr-2, Krox-20, Krox20, Zfp-25
Molecular mass of antigen [kDa]50
Distribution of antigenT cells, NK cells
Entrez Gene ID13654
RRIDAB_2726516, AB_2726587, AB_2726517, AB_2726588, AB_2726518, AB_2726589, AB_2726519, AB_2726586

References for EGR-2 Antibody, anti-mouse, REAfinity™

Publications

  1. Warner, L. E. et al. (1998) Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat. Genet. 18(4): 382-384
  2. Dillon, R. L. et al. (2007) An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol. Cell. Biol. 27(24): 8648-8657
  3. Chandra, A. et al. (2013) Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression. J. Biol. Chem. 288(28): 20488-20498

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