Clone:
REA696
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
EGFR, ERBB, HER1, NISBD2, PIG61, erbB-1

Specifications for EGF Receptor pY1173 Antibody, anti-human, REAfinity™

Overview

Clone REA696 recognizes the human epidermal growth factor receptor (EGFR) antigen phosphorylated at tyrosine 1173 (pY1173). EGFR is a single-pass type I membrane protein which is also known as receptor tyrosine-protein kinase ErbB-1 or HER1. It is a critical regulator of many normal cellular processes, including cell growth, differentiation, survival, and migration. The EGFR is also implicated in pathological processes of cellular transformation and oncogenesis due to its overexpression in many types of cancers and its ability to induce morphological transformation of cultured cells and tumor formation in nude mice. Many different signaling pathways have been discovered to mediate the effects of EGF, the most notable being Ras-mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3-kinase pathways. In these pathways EGF binds to the EGFR to induce dimerization, catalytic activation, and autophosphorylation of tyrosines in the C-terminal tail of the EGFR. These phosphorylated tyrosines provide docking sites for adapter proteins such as Grb2, Shc, and Gab2 to link the receptor to the Ras-MAPK, as well as phosphatidylinositol 3-kinase pathways.
Additional information: Clone REA696 displays negligible binding to Fc receptors.

Alternative names

EGFR, ERBB, HER1, NISBD2, PIG61, erbB-1

Detailed product information

Technical specifications

CloneREA696
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenEGF Receptor pY1173
Alternative names of antigenEGFR, ERBB, HER1, NISBD2, PIG61, erbB-1
Molecular mass of antigen [kDa]132
Distribution of antigenubiquitous
Entrez Gene ID1956
RRIDAB_2651611, AB_2651612, AB_2651613, AB_2651610

References for EGF Receptor pY1173 Antibody, anti-human, REAfinity™

Publications

  1. Ullrich, A. et al. (1984) Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309(5967): 418-425
  2. Heisermann, G. J. et al. (1988)
    Epidermal growth factor receptor threonine and serine residues phosphorylated
    in vivo
    .
    J. Biol. Chem. 263(26): 13152-13158

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