Clone:
JD3
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
TNFRSF25, Apo-3, DDR3, LARD, Tnfrsf12, TR3, TRAMP, WSL-1, WSL-LR

Specifications for DR3 Antibody, anti-human

Overview

Clone JD3 recognizes the human DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It mediates activation of NFκB and induces apoptosis. DR3 is expressed preferentially by activated and antigen-experienced T lymphocytes. It is also highly expressed by FoxP3-positive regulatory T lymphocytes. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen-presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation. Multiple alternatively spliced transcript variants of this gene-encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of DR3 in B and T cells encounters a programmed change upon T cell–activation, which predominantly produces full-length, membrane-bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T cell–activation. DR3 stimulation is therefore highly specific to T cell–mediated immunity, which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign versus self antigen availability. Stimulation of DR3 in humans leads to similar effects as costimulatory blockade targeting molecules such as CTLA-4 and PD-1.

Alternative names

TNFRSF25, Apo-3, DDR3, LARD, Tnfrsf12, TR3, TRAMP, WSL-1, WSL-LR

Detailed product information

Technical specifications

CloneJD3
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenDR3
Alternative names of antigenTNFRSF25, Apo-3, DDR3, LARD, Tnfrsf12, TR3, TRAMP, WSL-1, WSL-LR
Molecular mass of antigen [kDa]43
Distribution of antigenT cells, lymphocytes
Entrez Gene ID8718
RRIDAB_2651586, AB_2651587, AB_2651588, AB_2651589, AB_2651590, AB_2651585

References for DR3 Antibody, anti-human

Publications

  1. Meylan, F. et al. (2008) The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1): 79-89
  2. Kitson, J. et al. (1996) A death-domain-containing receptor that mediates apoptosis. Nature 384(6607): 372-375
  3. Chinnaiyan, A. M. et al. (1996) Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274(5289): 990-992

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DR3 Antibody, anti-human

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